By The National.Society.for the Prevention of Cruelty to Children Contributors
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Example text
E - s e l e c t i rne c o g n i z ecso m p l e xs i a l y l a t e d carbohydrate groups relatedto the Lewis X or Lewis A f a m i l yf o u n do n v a r i o u ss u r f a c ep r o t e i n so f g r a n u l o c y t e s , monocytes,and some previouslyactivatedeffectorand m e m o r yT c e l l s E - s e l e c t i ins i m p o r t a n itn m i g r a t i o no f Selectin lSize l e u k o c y t e si,n c l u d i n gn e u t r o p h i l sa n d o f e f f e c t o r a n d m e m o r yT c e l l st o s o m ep e r i p h e r asli t e so f i n f l a m m a t i o n .
H e g e n e sf o r t h e t h r e e s e l e c t i n as r el o c a t e di n t a n d e mo n c h r o m o s o m e 1 inboth m i c e a n d h u m a n s T h e d i f f e r e n c e sa m o n g t h e t h r e e s e l e c t r n ss e r v e t o c o n f e r d i f f e r e n c e sb o t h i n b i n d i n g s p e c i f r c i tay n d i n t i s s u ee x p r e s s i o nH. o w e v e r a , ll three selectinsmediaterapidlow-affinityattachmentof leukoc y t e s t o e n d o t h e l i u ma, n e a r l y a n d i m p o r t a n ts t e p i n l e u k o c y t eh o m i n g L - s e l e c t i (nC D 6 2 Li)s e x p r e s s e do n l y m p h o c y t eas n d o t h e rl e u k o c y t e sl t.
A third population of cells present under many epithelia and in serosal cavities are mast cells. Mast cells respond directly to microbial products by secreting cytokines and lipid mediators that promote inflammation. We will return to a discussion of mast cells in Chapter 19. These include cells of the myeloid lineage, including neutrophils, mononuclear phagocytes, and dendritic cells, which we will discuss in this section, and cells of the lymphocyte Iineage, including natural killer cells, which will be described later, as well as y6T cells and B-1 B cells,which were described above.
