By Fernando Albericio, Judit Tulla-Puche

Whereas many books hide strong section synthesis and combinatorial synthesis, this one is exclusive in its particular insurance of the opposite features of solid-phase synthesis. As such, it comprises every thing you must recognize -- from supported reagents, to scavengers, resins, and the synthesis of biomolecules and common products.
a useful better half for all chemists and biochemists operating in college examine and undefined.

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2006) Journal of Combinatorial Chemistry, 8, 652–4. , et al. (2004) Organic Letters, 6, 1405–8. Gu, W. B. (2003) Organic Letters, 5, 415–18. F. and Barany, G. (1997) Methods in Enzymology, 289, 126–74. J. C. (1975) Journal of the American Chemical Society, 97, 6584–5. R. and Haber, E. (1980) Analytical Biochemistry, 104, 215–27. Albericio, F. and Barany, G. (1984) International Journal of Peptide and Protein Research, 23, 342–9. B. (1978) J. Org. , 43, 2845–52. Meldal, M. (1997) Methods in Enzymology, 289, 83–104.

PSand PEG-based resins are the most widely used; however, syntheses can be carried out in any solid support. The development of new solid supports and linkers/ handles is crucial to fulfill the new requirements of modern drug discovery programs. 11 12 1 The (Classic Concept of) Solid Support Acknowledgments The work carried out in the laboratory of the authors was partially supported by CICYT (CTQ2006-03794/BQU), the Generalitat de Catalunya (2005SGR 00662), ISCIII (CIBER, nanomedicine 0074), the Institute for Research in Biomedicine, and the Barcelona Science Park.

E. the seed particle) and a shell of MIP [98, 99]. 5 Silica Composite Beads MIPs can be synthesized in the pores and on the surface of pre-made porous particles. Porous silica particles have been applied for this purpose. To ensure that the imprinted polymer is attached firmly to the particle, the particles are often chemically modified by coupling of polymerizable groups or initiator molecules to the particle surface prior to the MIP polymerization [100–102]. The use of immobilized initiators is often referred to as the iniferter (initiator–transfer agent– terminator) approach [103].

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