By L. Rosenberger, D. J. Triggle (auth.), George B. Weiss (eds.)

Anyone surveying physiological and pharmacological journals can without difficulty see that the organic activities of calcium ion are of more and more frequent present curiosity. The scope of investi­ gated activities and reactions within which a task for calcium ion is of a few significance is so various as to exhibit the impact that calcium ion is far and wide and interacts with every little thing. This being so, the problem in modern learn is to target research of these activities of calcium ion which, in a few demeanour, effect both major physiological parameters or the way within which pharmacological brokers act. This multi-authored booklet originated from a extra restricted Symposium on "Importance of Calcium as a prime Locus of Drug motion" co-chaired on my own and Dr. Frank R. Goodman on the April, 1977 FASEB assembly in Chicago. This Symposium was once prepared in line with a perceived desire for elevated conversation between 2 staff in several components of Ca +-related learn. within the seasoned­ cess of choosing the utmost of six parts for presentation in the layout supplied, it quickly turned obvious that this is able to bring about just a restricted sampling of present examine efforts. enlargement of the variety of components to 14 inside a publication layout looked to be the main logical mechanism to supply a extra coherent inter­ disciplinary method of attention of varied elements of the two roles of Ca + in drug motion. this isn't to indicate that each one rele­ 2 vant Ca +-related components are surveyed inside of this volume.

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Physiol. Pharmacol. 53: 110S. Thorn, N. , Russell, J. , and Robinson, I. C. A. , 1975, Factors affecting intracellular concentration of free calcium ions in neurosecretory nerve endings, in "Calcium Transport in Contraction and Secretion", (E. Carafoli, F. Clementi, W. Drabikowski, and A. ), pp. 261-269, North-Holland Publishing Company, Amsterdam. , 1970, Electrical properties of mammalian smooth muscle, in "Smooth Muscle", (E. BUlbring, A. F. Brading, A. W. Jones, and T. ), Williams and Wilkins, Baltimore, Md.

Pressmen, B. , 1974, The activation of sea-urchin eggs by the divalent cation ionophores A23l87 CALCIUM ENTRY AND ANTAGONISTS 25 and X-537A, Biochem. Biophys. Res. Commun. 60: 126. Cochrane, D. , and Douglas, W. , 1974, Calcium-induced extrusion of secretory granules (exocytosis) in mast cells exposed to 48/80 or the ionophores A-23l87 and X-537A, Proc. Nat. Acad. Sci. A. 71: 408. Cochrane, D. , Douglas, W. , 1975, Calcium and stimulus-secretion coupling in the adrenal medulla: contrasting stimulating effects of the ionophores X-537A and A23l87 on catecholamine output, J.

And Hibbs, R. , 1970, A comparative histochemical and electron microscopic study of the surface coatings of cardiac muscle cells, J. Mol. Cell. Cardiol. 1: 157. , Yabu, H. , 1975, Changes in contractility and calcium binding of guinea pig Taenia Coli by treatment with enzymes which hydrolyze sialic acid, Jpn. J. Physiol. 25: 719. Langer, G. , 1965, Calcium exchange in dog ventricular muscle: relation to frequency of contraction and maintenance of contractility, Circ. Res. 17: 78. Langer, G. , 1972, Effects of digitalis in myocardial ionic exchange, Circulation 46: 180.

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