By W. E. Johns

Biggles is requested to assist a chinese language resident of Malaysia, known as Lin Seng, circulation his special pearl assortment to London. among this necessary assortment is a wonderful pearl referred to as "the Blue Moon of Asia". Flying out to Malaysia and over Taihan, Seng's amazing domestic, Biggles reveals no appropriate touchdown position. Going to Kuala Lumpur, Biggles makes touch with considered one of Seng's company managers known as Tong. He tells Biggles that mobile touch has been misplaced with Taihan. Biggles and Algy rent a vehicle and force out to enquire. discovering a holiday within the telegraph traces, Biggles discovers the physique of a put up place of work employee despatched out to fix the fault. The strains were lower and whilst Biggles fetches the neighborhood police, the physique has disappeared. urgent directly to Lin Seng's domestic at Taihan, Biggles reveals he's below siege from thieves who are looking to thieve his pearl assortment. Twenty unswerving employees guard Seng. Algy makes use of those employees to begin to transparent an overgrown golfing path to show it right into a makeshift touchdown strip. the location takes a flip for the more severe while information is acquired that 50 Indonesian guerrillas have landed and are suspected to be making for Taihan. Biggles makes a decision to aim to damage out, to get to Kuala Lumpur while Algy finishes the airstrip. right here he can alert the Malaysian executive to the Indonesian incursion and convey the aircraft to Taihan to land and gather Lin Seng and his pearls. Leaving by means of automobile with Ayart, certainly one of Seng's servants, Biggles is dropped at a halt and captured through the thieves within the jungle. Algy makes a decision to dam the doorway to the golfing path by way of destroying a fallen tree over a crocodile infested ditch. utilizing gelignite, he blows the tree to items and this is helping facilitate Biggles' get away as the thieves have been taking Biggles to the golfing path and they're stuck within the explosion. completing the airstrip, Algy and Lin Seng are getting ready for evacuation while the Indonesian troops assault. Biggles arrives via airplane and with him come Malaysian govt squaddies. Algy saves Lin Seng from a murderous assault with a purpose to scouse borrow his pearls and he's eventually flown to protection. the image at the airborne dirt and dust disguise exhibits Algy approximately to blow-up the tree bridge below a staring at moon.

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Instead the low risk breast cancer group excreted decreased levels of estrone and l7S-estradiol. g. estriol) "protects" target tissues from the carcinogenic (77,81) effect of the more active estrogens. Since pregnancy results in very high levels of urinary estriol, this viewpoint has been extrapolated to explain the protecting effect of early first pregnancy on the incidence of breast *During the preparation of this manuscript an excellent review entitled "Hormone Profiles in Hormone-Dependent Cancers" by B.

In experimental animals hepatic mixed oxidases (cytochrome P450) are known to be involved in steroid hydroxlations (52). These microsomal enzymes are responsible for the hydroxylation of steroids at positions 2,68, 78, l5a, l6a, l7a and 21 (28-33,53,54). Other substrates such as fatty acids, drugs, anesthetics, insecticides, and carcinogens are also hydroxylated or OXidatively N-demethylated by this system in the presence of NADPH and oxygen. Both androgens and corticosteroids have been shown to activate this hepatic microsomal mono-oxygenase system although through different mechanisms (55).

Urine specimens were collected from some 5,000 healthy women. When breast cancer was subsequently discovered in a woman, her prediagnosis excretion of l7-ketosteroids and l7ahydroxycorticosteroids was compared with matched controls. At the time of publication 27 women had presented with breast cancer. The mean excretion of etiocholanolone in the precancer cases was significantly lower than that of the matched controls. This abnormality in l7-ketosteroids excretion was found at all ages and was seen as early as nine years prior to the diagnosis of breast cancer.

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